Triphenylphosphine → HCID 58557391, compound

Temperature

50 °C

To a solution of tert-butyl 2-ethyl-4-((methylsulfonyloxy)methyl)cyclopentanecarboxylate (0.295 g, 0.964 mmol) in DMF (5 mL) was added sodium azide (0.313 g, 4.82 mmol). The reaction was heated at about 50° C. for about 16 h and then cooled to about 15-20° C. Water (40 mL) was added to the reaction mixture. The aqueous solution was extracted with DCM (3×30 mL). The combined organic extracts were dried over anhydrous MgSO4, filtered, and concd under reduced pressure to give a dark brown oil. The brown oil was dissolved in THF (6.5 mL) and water (3.5 mL). Triphenylphosphine (0.316 g, 1.205 mmol) was added. The reaction mixture was stirred at about 25° C. for about 15 h. The organic solvent was removed under reduced pressure and the residue partitioned between saturated aqueous NaHCO3 (20 mL) and DCM (20 mL). The organic phase was concd under reduced pressure. The resulting residue was purified using silica gel chromatography eluting with a gradient of 0-20% (20% (7 N ammonium in MeOH) in MeOH)) in DCM to give tert-butyl 4-(aminomethyl)-2-ethylcyclopentanecarboxylate (0.102 g, 46%) as a brown oil: LC/MS (Table 1, Method b) Rt=1.72 min; MS m/z: 228 (M+H)+.

1. temperaturecooled to about 15-20° C
2. extractionThe aqueous solution was extracted with DCM (3×30 mL)
3. dry with materialThe combined organic extracts were dried over anhydrous MgSO4
4. filtrationfiltered
5. customconcd under reduced pressure to give a dark brown oil
6. customThe organic solvent was removed under reduced pressure
7. customthe residue partitioned between saturated aqueous NaHCO3 (20 mL) and DCM (20 mL)
8. customThe resulting residue was purified
9. washeluting with a gradient of 0-20% (20% (7 N ammonium in MeOH) in MeOH)) in DCM

ORD record

ord-08d6b89d814d4e65b2a8293c274a5cf6

Source dataset

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08426411B2