Acetic Acid → Ethyl 4-[bis(phenylmethyl)amino]cyclohexanecarboxylate

HRID 1969902Notes

Reaction equation

HRID 1969902 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.CC(O)=O.[CH2:17]([NH:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>O.C1COCC1>[CH2:25]([N:24]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:2]1[CH2:7][CH2:6][CH:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

7

Reactant 4

HCID 176Acetic AcidHCID 7656DibenzylamineHCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 22287000Ethyl 4-[bis(phenylmethyl)amino]cyclohexanecarboxylateYield 72%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A 250 mL flask was charged with ethyl 4-oxocyclohexanecarboxylate (5 g, 28.5 mmol, Alfa Aesar) and THF (75 mL). The solution was cooled to about 0° C. and AcOH (2.28 mL, 39.9 mmol) and dibenzylamine (6.18 g, 31.3 mmol) (TCI) were added dropwise, resulting in formation of a thick suspension. Na(OAc)3BH (14.3 g, 64.1 mmol) was added portionwise and the reaction mixture was stirred at ambient temperature for about 72 h. The reaction mixture was cooled to about 10° C. Water (25 mL) was added and the reaction mixture was stirred for about 15 min. Heptanes (50 mL) were added. The layers were separated and the organic layer was washed with 10% aqueous AcOH solution (25 mL) and then with water (10 mL). The organic layer was extracted with 4% HCl solution twice (40 mL and 20 mL). The combined aqueous layer was washed with heptanes (20 mL). To the aqueous layer was slowly added 30% aqueous K2CO3 solution (30 g) to adjust the pH to 10. The aqueous solution was extracted with heptane twice (75 mL and 15 mL). The combined organic layer was washed with water (30 mL). The organic layer was dried over anhydrous Na2SO4 and filtered. The filtrate was concd under reduced pressure to give ethyl 4-(dibenzylamino)cyclohexanecarboxylate (7.2 g, 72%) as an oil which solidified upon standing: LC/MS (Table 1, Method a) Rt=3.18 and 3.23 min; MS m/z: 352 (M+H)+.

Workup

  1. customresulting in formation of a thick suspension
  2. temperatureThe reaction mixture was cooled to about 10° C
  3. stirringthe reaction mixture was stirred for about 15 min
  4. customThe layers were separated
  5. washthe organic layer was washed with 10% aqueous AcOH solution (25 mL)
  6. extractionThe organic layer was extracted with 4% HCl solution twice (40 mL and 20 mL)
  7. washThe combined aqueous layer was washed with heptanes (20 mL)
  8. extractionThe aqueous solution was extracted with heptane twice (75 mL and 15 mL)
  9. washThe combined organic layer was washed with water (30 mL)
  10. dry with materialThe organic layer was dried over anhydrous Na2SO4
  11. filtrationfiltered

Sources & evidence

ORD record
ord-252036b59b584ce8ba83b261615c9240
Source dataset
uspto-grants-2013_04
Patent number
US08426411B2

Reaction notes

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