反应详情

To a solution of 355 mg 5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carboxylic acid in 3 ml DMF were added 356 μl DIPEA, 328 mg HATU and 400 mg 4-((S)-2-amino-4-benzyloxy-butyryl)-piperazine-1-carboxylic acid ethyl ester hydrotrifluoroacetate. After stirring for 12 h the reaction mixture was diluted with ethyl acetate and subsequently washed with aqueous LiCl (4%), 0.1 M HCl and saturated NaHCO3. The crude product obtained after evaporation of the solvent was used without further purification. Yield: 543 mg.

1. washsubsequently washed with aqueous LiCl (4%), 0.1 M HCl and saturated NaHCO3