反应详情

To a solution of 5-{[(1-adamantylmethyl)amino]carbonyl}imidazo[1,2-a]pyridine-2-carboxylic acid (25 mg, 0.071 mmol) in DMF (2 mL) is sequentially added 0.05 mL of DIEA, 15.8 mg of tert-butyl (3R)-pyrrolidin-3-ylcarbamate (0.085 mmol) and 37.6 mg of BOP (0.085 mmol). After stirring for 2 h at RT, the reaction mixture is diluted with EtOAc and water. The organic layer is separated, and the aqueous layer is back extracted with EtOAc. The combined organic layers are washed with water and brine, dried over sodium sulfate, and concentrated. Purification of the residue by PTLC (8% MeOH, 1% NH4OH in DCM) affords the title compound.

1. customThe organic layer is separated
2. extractionthe aqueous layer is back extracted with EtOAc
3. washThe combined organic layers are washed with water and brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customPurification of the residue by PTLC (8% MeOH, 1% NH4OH in DCM)