Methanesulfonic Acid → HCID 86635066, compound

HRID 1971803Notes

Reaction equation

HRID 1971803 reaction equation
[CH:1]1([CH2:5][N:6]([CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[C:7]2[C:8]([O:28][CH3:29])=[N:9][N:10]3[C:14]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][C:18]([CH2:23][O:24][CH3:25])=[CH:17][C:16]=4[O:26][CH3:27])=[CH:13][S:12][C:11]=23)[CH2:4][CH2:3][CH2:2]1.[CH3:36][S:37]([OH:40])(=[O:39])=[O:38]>C(OCC)(=O)C>[CH3:36][S:37]([OH:40])(=[O:39])=[O:38].[CH:1]1([CH2:5][N:6]([CH:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)[C:7]2[C:8]([O:28][CH3:29])=[N:9][N:10]3[C:14]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][C:18]([CH2:23][O:24][CH3:25])=[CH:17][C:16]=4[O:26][CH3:27])=[CH:13][S:12][C:11]=23)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 57912434HCID 57912434, compound

Product 1

HCID 86635066HCID 86635066, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of N-(cyclobutylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (26.2 mg) and ethyl acetate (1.0 mL) was added methanesulfonic acid (3.40 μL). The mixture was stirred at room temperature for 1 hour and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (31.2 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-c5b92cf19e074156b600126a0c2eaf56
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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