Hydrochloric Acid → HCID 68983762, compound

HRID 1971805Notes

Reaction equation

HRID 1971805 reaction equation
[CH:1]1([CH2:4][N:5]([CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:6]2[C:7]([O:27][CH3:28])=[N:8][N:9]3[C:13]([C:14]4[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH2:22][O:23][CH3:24])=[CH:16][C:15]=4[O:25][CH3:26])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:41]>C(OCC)C>[ClH:41].[CH:1]1([CH2:4][N:5]([CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:6]2[C:7]([O:27][CH3:28])=[N:8][N:9]3[C:13]([C:14]4[C:15]([O:25][CH3:26])=[CH:16][C:17]([CH2:22][O:23][CH3:24])=[CH:18][C:19]=4[O:20][CH3:21])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 57912458HCID 57912458, compound

Product 1

HCID 68983762HCID 68983762, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (8.38 mg) and ethyl acetate (0.5 mL) was added hydrochloric acid in diethyl ether (1M, 17.2 μL). The mixture was stirred at room temperature for 1.5 hours and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (9.22 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-c1fc64b157814c95817a18919fa4d273
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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