Hydrochloric Acid → HCID 68515566, compound

HRID 1971806Notes

Reaction equation

HRID 1971806 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][O:10][CH3:11])[CH:6]=[C:5]([O:12][CH3:13])[C:4]=1[C:14]1[N:15]2[N:21]=[C:20]([O:22][CH3:23])[C:19]([N:24]([CH2:31][CH2:32][CH3:33])[CH:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[C:16]2[S:17][CH:18]=1.C(OCC)(=O)C.[ClH:40]>C(OCC)C>[ClH:40].[CH3:13][O:12][C:5]1[CH:6]=[C:7]([CH2:9][O:10][CH3:11])[CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:14]1[N:15]2[N:21]=[C:20]([O:22][CH3:23])[C:19]([N:24]([CH2:31][CH2:32][CH3:33])[CH:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[C:16]2[S:17][CH:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 57912441HCID 57912441, compound

Product 1

HCID 68515566HCID 68515566, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (6.98 mg) and ethyl acetate (0.5 mL) was added hydrochloric acid in diethyl ether (1M, 14.7 μL). The mixture was stirred at room temperature for 1.5 hours and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (7.84 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-dd154217b7544b28b7eb33fdae6906f0
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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