Methanesulfonic Acid → HCID 86635068, compound

HRID 1971808Notes

Reaction equation

HRID 1971808 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][O:10][CH3:11])[CH:6]=[C:5]([O:12][CH3:13])[C:4]=1[C:14]1[N:15]2[N:21]=[C:20]([O:22][CH3:23])[C:19]([N:24]([CH2:31][CH:32]3[CH2:34][CH:33]3[CH3:35])[CH:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[C:16]2[S:17][CH:18]=1.[CH3:36][S:37]([OH:40])(=[O:39])=[O:38]>C(OCC)(=O)C>[CH3:36][S:37]([OH:40])(=[O:39])=[O:38].[CH3:13][O:12][C:5]1[CH:6]=[C:7]([CH2:9][O:10][CH3:11])[CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:14]1[N:15]2[N:21]=[C:20]([O:22][CH3:23])[C:19]([N:24]([CH2:31][CH:32]3[CH2:34][CH:33]3[CH3:35])[CH:25]3[CH2:26][CH2:27][O:28][CH2:29][CH2:30]3)=[C:16]2[S:17][CH:18]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 57912438HCID 57912438, compound

Product 1

HCID 86635068HCID 86635068, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-[(2-methylcyclopropyl)methyl]-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (14.6 mg) and ethyl acetate (0.5 mL) was added methanesulfonic acid (1.90 μL). The mixture was stirred at room temperature for 1 hour and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (17.4 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-544c1ece31da42b59b919b483b1f1a85
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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