Hydrochloric Acid → HCID 68516475, compound

HRID 1971811Notes

Reaction equation

HRID 1971811 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:28][CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:6]2[C:7]([O:26][CH3:27])=[N:8][N:9]3[C:13]([C:14]4[C:21]([O:22][CH3:23])=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=4[O:24][CH3:25])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:41]>C(OCC)C>[ClH:41].[CH:1]1([CH2:4][N:5]([CH2:28][CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:6]2[C:7]([O:26][CH3:27])=[N:8][N:9]3[C:13]([C:14]4[C:15]([O:24][CH3:25])=[CH:16][C:17]([C:18]#[N:19])=[CH:20][C:21]=4[O:22][CH3:23])=[CH:12][S:11][C:10]=23)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 44478736HCID 44478736, compound

Product 1

HCID 68516475HCID 68516475, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of 4-{7-[(cyclopropylmethyl)(tetrahydro-2H-pyran-4-ylmethyl)amino]-6-methoxypyrazolo[5,1-b][1,3]thiazol-3-yl}-3,5-dimethoxybenzonitrile (26.4 mg) and ethyl acetate (0.5 mL) was added hydrochloric acid in diethyl ether (1M, 54.7 μL). The mixture was stirred at room temperature for 1 hour and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (28.4 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-6ef5aef3fe6f43a6aac72fd10ab426e6
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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