Hydrochloric Acid → HCID 68517551, compound

HRID 1971812Notes

Reaction equation

HRID 1971812 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:28][CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:6]2[C:7]([O:26][CH3:27])=[N:8][N:9]3[C:13]([C:14]4[C:19]([O:20][CH3:21])=[CH:18][C:17]([O:22][CH3:23])=[CH:16][C:15]=4[O:24][CH3:25])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:41]>C(OCC)C>[ClH:41].[CH:1]1([CH2:4][N:5]([CH2:28][CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:6]2[C:7]([O:26][CH3:27])=[N:8][N:9]3[C:13]([C:14]4[C:15]([O:24][CH3:25])=[CH:16][C:17]([O:22][CH3:23])=[CH:18][C:19]=4[O:20][CH3:21])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 44478737HCID 44478737, compound

Product 1

HCID 68517551HCID 68517551, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of N-(Cyclopropylmethyl)-6-methoxy-N-(tetrahydro-2H-pyran-4-ylmethyl)-3-(2,4,6-trimethoxyphenyl)-pyrazolo[5,1-b][1,3]thiazole-7-amine (6.51 mg) and ethyl acetate (0.5 mL) was added hydrochloric acid in diethyl ether (1M, 13.4 μL). The mixture was stirred at room temperature for 1.5 hours and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (7.41 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-2f31f1b405004b3b90e915b6de3fe4c0
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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