反应详情

A mixture of the product of example 3 (1.0 g, 2.358 mmol) and LiOH (aq., 1N, 14 ml) in THF (10 ml) was stirred at room temperature for about 3 hours. Then diluted HCl (1N) was added dropwise to adjust the pH ˜2. The resulting solids were collected by filtration, washed with ethyl acetate and dried to give the titled compound (740 mg, yield 76.3%).

1. filtrationThe resulting solids were collected by filtration
2. washwashed with ethyl acetate
3. customdried