Hydrochloric Acid → HCID 58126863, compound

HRID 1971817Notes

Reaction equation

HRID 1971817 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]2[N:22]([CH2:23][C:24](=[O:31])[N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH:21]=[CH:20][N:8]2[C:9](=[O:19])[C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:4].[Li+].[OH-].Cl>C1COCC1>[CH2:12]([O:11][C:10]1[C:9](=[O:19])[N:8]2[CH:20]=[CH:21][N:22]([CH2:23][C:24](=[O:31])[N:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[C:7]2=[N:6][C:5]=1[C:3]([OH:4])=[O:2])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 58126934HCID 58126934, compound

Product 1

HCID 58126863HCID 58126863, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the product of example 3 (1.0 g, 2.358 mmol) and LiOH (aq., 1N, 14 ml) in THF (10 ml) was stirred at room temperature for about 3 hours. Then diluted HCl (1N) was added dropwise to adjust the pH ˜2. The resulting solids were collected by filtration, washed with ethyl acetate and dried to give the titled compound (740 mg, yield 76.3%).

Workup

  1. filtrationThe resulting solids were collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-23e956fec16e4d53b36bde2c9d8db5e5
Source dataset
uspto-grants-2013_04
Patent number
US08431581B2

Reaction notes

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