Sodium Bicarbonate → 3-Cyclopropylthiomorpholine 1,1-dioxide

HRID 1972456Notes

Reaction equation

HRID 1972456 reaction equation
Cl.[CH:2]1([CH:5]2[CH2:10][S:9](=[O:12])(=[O:11])[CH2:8][CH2:7][NH:6]2)[CH2:4][CH2:3]1.C([O-])(O)=O.[Na+]>CCOC(C)=O>[CH:2]1([CH:5]2[CH2:10][S:9](=[O:11])(=[O:12])[CH2:8][CH2:7][NH:6]2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 665826493-Cyclopropylthiomorpholine 1,1-dioxide hydrochloride

Product 1

HCID 644373453-Cyclopropylthiomorpholine 1,1-dioxideYield 96.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 100 mL round-bottomed flask was charged with 3-cyclopropylthiomorpholine 1,1-dioxide hydrochloride (1.00 g, 4.72 mmol) and 10 mL of EtOAc. To this was added 15 mL of saturated aqueous NaHCO3. After stirring at room temperature for 15 min, the layers were separated. The organics were dried (MgSO4), filtered, and concentrated to give 3-cyclopropylthiomorpholine 1,1-dioxide (0.800 g) as a colorless oil.

Workup

  1. customthe layers were separated
  2. dry with materialThe organics were dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-7149c6430c64448da0520be0a75968d2
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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