Carbon tetrabromide → HCID 58529675, compound

HRID 1972788Notes

Reaction equation

HRID 1972788 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:16]3[CH:17]=[CH:18][C:19]4[C:23]([CH:24]=3)=[N:22][N:21]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:20]=4)[CH:9]=[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]O)[N:6]2[N:5]=[CH:4][N:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:52]>O1CCCC1>[CH2:25]([N:21]1[CH:20]=[C:19]2[C:23]([CH:24]=[C:16]([C:8]3[CH:9]=[C:10]([CH2:11][CH2:12][CH2:13][CH2:14][Br:52])[N:6]4[C:7]=3[C:2]([NH2:1])=[N:3][CH:4]=[N:5]4)[CH:17]=[CH:18]2)=[N:22]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 58529601HCID 58529601, compound

Product 1

HCID 58529675HCID 58529675, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a cooled (0° C.) solution of 4-(4-amino-5-(2-benzyl-2H-indazol-6-yl)pyrrolo[2,1-f][1,2,4)triazin-7-yl]butan-1-ol (2.54 g, 6.16 mmol) and triphenylphosphine (2.42 g, 9.24 mmol) in tetrahydrofuran (30 mL) was added carbon tetrabromide (2.45 g, 7.39 mmol).

Sources & evidence

ORD record
ord-15bfe33a07c24d3e8a260502f292473b
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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