Hydrochloric Acid → HCID 258700, compound

HRID 1973057Notes

Reaction equation

HRID 1973057 reaction equation
[C:1]1([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].CN(C)C=O.Cl>O>[C:1]1([C:7]2[CH:14]=[CH:13][C:10]([CH:11]=[CH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 14797Potassium HydroxideHCID 76689(1,1'-Biphenyl)-4-carboxaldehyde

Product 1

HCID 258700HCID 258700, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 24.0 parts of the compound of formula ##STR18## 25.8 parts of p-phenylbenzaldehyde-anile and 50.0 parts of potassium hydroxide powder in 600.0 parts by volume of dimethyl formamide is raised to 60° in 30 minutes with stirring and in the absence of air. It is maintained at this temperature for a further 30 minutes, after which it is cooled to about 10°. At a temperature between 10° and 20° 20 parts of water and then 500.0 parts by volume of 10% hydrochloric acid are added. The precipitated product is filtered off with suction, washed with water until neutral and dried. The 4-(5"-methoxybenzoxazolyl-2")-4'-phenylstilbene of formula (10) is obtained in very good yield. It can be purified as described above.

Workup

  1. temperatureis raised to 60° in 30 minutes
  2. temperatureIt is maintained at this temperature for a further 30 minutes
  3. temperatureafter which it is cooled to about 10°
  4. filtrationThe precipitated product is filtered off with suction
  5. washwashed with water until neutral and
  6. customdried

Sources & evidence

ORD record
ord-25e6d5123d5d481990950c26f4ea28d2
Source dataset
uspto-grants-1976_12
Patent number
US03996210

Reaction notes

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