HCID 21491287, compound → HCID 178487977, compound

HRID 1973365Notes

Reaction equation

HRID 1973365 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:15]([OH:17])=O)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2.[NH2:18][C:19]1[NH:23][N:22]=[N:21][N:20]=1>O1CCCC1.CN(C)C=O>[CH3:1][O:2][C:3]1[C:4]([C:15]([NH:18][C:19]2[NH:23][N:22]=[N:21][N:20]=2)=[O:17])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2

Participants

5

Reactant 2

HCID 21491287HCID 21491287, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178487977HCID 178487977, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolvent

Procedure

3,6-Dimethoxy-2-quinoxalinecarboxylic acid (Example 12c) (2 g) and N,N'-carbonyldiimidazole (1.4 g) in tetrahydrofuran (50 ml) were heated under reflux for 15 minutes. 5-Amino-1H-tetrazole (0.8 g) in dimethylformamide (5 ml) was added and the mixture was heated under reflux for a further 30 minutes. The solid that crystallised from the solution on cooling was collected and dried. It had m.p. 250°-251° (d) (59%).

Workup

  1. temperatureunder reflux for 15 minutes
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for a further 30 minutes
  4. customThe solid that crystallised from the solution
  5. temperatureon cooling
  6. customwas collected
  7. customdried

Sources & evidence

ORD record
ord-57870fac1178415fb21361cc87291bbf
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

Loading…