HRID1973597

反应详情

EQUATION

反应方程式

HRID 1973597 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

PROCEDURE

实验过程

The starting material can be obtained according to the procedure of A. R. Todd and F. Bergel, J. Chem. Soc. 1937, 366 from p-n-butoxybenzamidine hydrochloride and ethoxymethylenemalonic acid diethyl ester with sodium ethylate in ethanol and subsequent treatment of the obtained 2-(p-n-butoxyphenyl)-4-hydroxy-5-pyrimidinecarboxylic acid ethyl ester (melting point 219.0°-220.0° C) with phosphorus oxychloride. The melting point of 2-(p-n-butoxyphenyl)-4-chloro-5-pyrimidinecarboxylic acid ethyl ester is 81.0°-81.5° C.

WORKUP

后处理

  1. customThe starting material can be obtained
  2. customis 81.0°-81.5° C.