Hydroxylamine → 1-Methoxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

HRID 1973911Notes

Reaction equation

CO[CH:3]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[CH:6]([N:12]=[C:13]=[O:14])[CH2:5][CH2:4]1.C(N)C#C.CON.NO.C(ON)CCC.[CH3:30][NH:31][O:32][CH3:33]>>[CH3:30][N:31]([O:32][CH3:33])[C:13]([NH:12][CH:6]1[C:7]2[CH:11]=[CH:10][S:9][C:8]=2[CH2:3][CH2:4][CH2:5]1)=[O:14]

Participants

Reactant 6

HCID 787Hydroxylamine

HCID 4113O-Methylhydroxylamine

HCID 14232N,O-Dimethylhydroxylamine

HCID 239041Propargylamine

HCID 3014370O-Butylhydroxylamine

HCID 214909524-Isocyanato-7-methoxy-4,5,6,7-tetrahydro-1-benzothiophene

Product 1

HCID 203489501-Methoxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Procedure

Similarly, 4,5,6,7-tetrahydro-7-methoxybenzo[b]-thien-4-ylisocyanate is allowed to react with propargylamine, methoxyamine, hydroxylamine, n-butoxyamine and methylmethoxyamine to afford 1-propynyl-, 1-methoxy-, 1-hydroxy-, 1(-n-butoxy)-, and 1-methyl-1-methoxy-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, respectively.

Sources & evidence

ORD record: ord-f00cf80485694188a49308dd00decd0d
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03998959

Reaction notes

Loading…