Hydrochloric Acid → HCID 19099371, compound

Temperature

-70 °C

4-tert-butylcyclohexancarboxilic acid (2.76 g, 0.015 mol), cis/trans mixture 1:1, in anhydrous THF (10 cm3) was added dropwise to a stirred suspension of LiAlH4 (1.14 g, 0.030 mol) in anhydrous THF (10 cm3), under atmosphere of nitrogen. After 2 h at room temperature the solution was thinned with ether and, under stirring, HCl (10% b.w.) was slowly added dropwise till acidic pH. The two layer were separated and the organic one was washed, then added with Na2SO4 and thoroughly dried under reduced pressure. The residue (2.5 g) was dissolved in anhydrous ether (10 cm3), cooled to -70° C., to which was added dropwise and with stirring PBr3 (1.5 g, 0.055 mol). After the addition was complete the mixture was stirred under reflux to room temperature for 2 h; ether was added and then some satured NaHCO3 solution. After the two layers were separated, Na2SO4 was added to the organic phase which was then dried under reduced pressure. Chromatography on silica gel eluting with hexane gave 1.1 g of 4-tert-butyl-cyclohex-2-enylmethyl bromide (trans isomer) out of 2.4 g of residue. Such product was employed in the example 4.

1. customThe two layer were separated
2. washthe organic one was washed
3. additionadded with Na2SO4
4. customthoroughly dried under reduced pressure
5. dissolutionThe residue (2.5 g) was dissolved in anhydrous ether (10 cm3)
6. additionAfter the addition
7. stirringwas stirred
8. temperatureunder reflux to room temperature for 2 h
9. customAfter the two layers were separated
10. additionNa2SO4 was added to the organic phase which
11. customwas then dried under reduced pressure

ORD record

ord-4d362c7c7c0b46a4a2b28b9ca00b5bb8

Source dataset

uspto-grants-1994_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05286725