Diethylamine → (3-Ethynyl-phenyl)-(6-pyridin-2-ylethynyl-quinazolin-4-yl)-amine

HRID 1975981Notes

Reaction equation

HRID 1975981 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17](I)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1)#[CH:2].[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1)#[CH:22].C(NCC)C>CN(C=O)C>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:22]#[C:21][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1)#[CH:2]

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 137268EthynylpyridineHCID 22000138(3-Ethynyl-phenyl)-(6-iodo-quinazolin-4-yl)-amine

Product 1

HCID 53905550(3-Ethynyl-phenyl)-(6-pyridin-2-ylethynyl-quinazolin-4-yl)-amine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was synthesized according to the method of Example 2 using (3-Ethynyl-phenyl)-(6-iodo-quinazolin-4-yl)-amine (125 mg, 0.506 mmol), 2-ethynyl-pyridine (66 mg, 0.505 mmol) and diethyl amine (72 mg, 0.99 mmol) in 2 mL, of DMF.

Sources & evidence

ORD record
ord-5f485029b2a7405eb08c8ee661cf2918
Source dataset
uspto-grants-2001_05
Patent number
US06225318B1

Reaction notes

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