Benzaldehyde → (Z)-Benzaldehyde oxime

Temperature

35 °C

To a solution of benzaldehyde (2.0 g, 19 mmol) in 1,4-dioxane (6.0 ml) was added hydroxylamine hydrochloride (1.3 g, 19 mmol) and triethylamine (2.6 ml, 19 mmol). The mixture was sonicated for 0.5 h and stirred at room temperature for 116 h and at 35° C. for 24 h. The solvent was removed in vacuo and the residue was dissolved in dichloromethane and washed with water, dried (MgSO4), filtered and evaporated in vacuo affording 1.9 g (84%) of benzaldehyde oxime as an oil.

1. customThe mixture was sonicated for 0.5 h
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in dichloromethane
4. washwashed with water
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customevaporated in vacuo

ORD record

ord-8ccda58d452e4037998433d57b85283c

Source dataset

uspto-grants-2001_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06225329B1