Dicyclohexylamine → HCID 178420472, compound

HRID 1976301Notes

Reaction equation

HRID 1976301 reaction equation
[CH:1]1([NH:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:14]([CH2:17][C:18]1([CH3:43])[CH2:27][CH2:26][C:25]2[C:20](=[C:21]([CH3:42])[C:22]([CH3:41])=[C:23]([S:29]([NH:32][C:33](=[NH:40])[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)(=[O:31])=[O:30])[C:24]=2[CH3:28])[O:19]1)([OH:16])=[O:15].C(OC(C)C)(C)C>CCOC(C)=O>[CH:8]1([NH:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1.[C:14]([CH2:17][C:18]1([CH3:43])[CH2:27][CH2:26][C:25]2[C:20](=[C:21]([CH3:42])[C:22]([CH3:41])=[C:23]([S:29]([NH:32][C:33](=[NH:40])[C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)(=[O:30])=[O:31])[C:24]=2[CH3:28])[O:19]1)([OH:16])=[O:15]

Participants

5

Reactant 3

HCID 7582DicyclohexylamineHCID 7914Diisopropyl EtherHCID 178427483HCID 178427483, compound

Product 1

HCID 178420472HCID 178420472, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of dicyclohexylamine (0.54 g) in AcOEt (1 ml) was added to a solution of N-(2-carboxymethyl-2,5,7,8-tetramethylchroman-6-sulfonyl)benzamidine (1.27 g) in AcOEt (11 ml) at room temperature. Diisopropyl ether (10 ml) was added and the mixture was stirred at room temperature to give N-(2-carboxymethyl-2,5,7,8-tetramethylchroman-6-sulfonyl)benzamidine dicyclohexylamine salt as a solid (1.59 g).

Sources & evidence

ORD record
ord-441e4b1b9c6a49ea94c10e65aa399b47
Source dataset
uspto-grants-2001_05
Patent number
US06225480B1

Reaction notes

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