Sodium Iodide → HCID 69804715, compound

HRID 1976392Notes

Reaction equation

HRID 1976392 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C:4]([N:6]([CH2:18][CH2:19][CH2:20]Cl)[S:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)(=[O:9])=[O:8])=[CH2:5].[I-].[Na+].[CH2:25]([NH2:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.C(N(C(C)C)CC)(C)C>CN(C=O)C>[CH3:1][O:2][C:3]([CH:4]1[CH2:5][N:32]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:20][CH2:19][CH2:18][N:6]1[S:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)(=[O:9])=[O:8])=[O:22]

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 7504BenzylamineHCID 81531DiisopropylethylamineHCID 69803844HCID 69803844, compound

Product 1

HCID 69804715HCID 69804715, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 0.910 g (0.2.619 mmol) of the product of Example 44 in 30 mL of DMF was added 0.432 g (0.2.881 mmol) of sodium iodide. The reaction was stirred for 30 min at room temperature and then 0.590 mL (5.499 mmol) of benzylamine and 0.96 mL (5.499 mmol) of diisopropylethylamine was added and the resulting mixture was heated at 80 degrees for 3 h and then cooled to room temperature.

Workup

  1. temperaturethe resulting mixture was heated at 80 degrees for 3 h
  2. temperaturecooled to room temperature

Sources & evidence

ORD record
ord-2537369409254cb19d6ffa66699d953e
Source dataset
uspto-grants-2001_05
Patent number
US06225311B1

Reaction notes

Loading…