Hydrochloric Acid → HCID 10142602, compound

HRID 1976404Notes

Reaction equation

HRID 1976404 reaction equation
CN1CCNCC1.[CH2:8]([O:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([N:22]([CH2:31][CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]2)[CH:23]([CH:28]([CH3:30])[CH3:29])[C:24]([NH:26][OH:27])=[O:25])(=[O:21])=[O:20])=[CH:15][CH:14]=1)[C:9]#[C:10][CH3:11].[ClH:41]>>[ClH:41].[CH2:8]([O:12][C:13]1[CH:14]=[CH:15][C:16]([S:19]([N:22]([CH2:31][CH2:32][CH2:33][N:34]2[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]2)[CH:23]([CH:28]([CH3:30])[CH3:29])[C:24]([NH:26][OH:27])=[O:25])(=[O:21])=[O:20])=[CH:17][CH:18]=1)[C:9]#[C:10][CH3:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 10073901HCID 10073901, compound

Product 1

HCID 10142602HCID 10142602, compound

Procedure

According to the procedure of Example 118, using 1-methylpiperazine instead of diethylamine, 2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(3-chloropropyl)-amino-3-3-methylbutanoate was converted into 2-{{[4-(2-butynyloxy)phenyl]sulfonyl}-[3-(4-methyl-1-piperazinyl)propyl]amino}-N-hydroxy-3-methylbutanamide, which was converted into the corresponding hydrochloride salt with ethereal HCl solution to provide an off-white solid. Electrospray Mass Spec 481.4 (M+H)+

Workup

  1. customto provide an off-white solid

Sources & evidence

ORD record
ord-40f65fcec90145f3a3e4732bfedf4877
Source dataset
uspto-grants-2001_05
Patent number
US06225311B1

Reaction notes

Loading…