Dimethylformamide → HCID 21997014, compound

HRID 1978224Notes

Reaction equation

HRID 1978224 reaction equation
Br[CH2:2][C:3](=[CH2:7])[C:4]([OH:6])=[O:5].[CH3:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][SH:16].CN(C)C=O>C(OCC)(=O)C>[CH2:15]([S:16][CH2:2][C:3](=[CH2:7])[C:4]([OH:6])=[O:5])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 81441-OctanethiolHCID 5588842-(Bromomethyl)propenoic acid

Product 1

HCID 21997014HCID 21997014, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2-bromomethylacrylic acid (1.0 g, 6.0 mmol), n-octylthiol (1.2 mL, 6.6 mmol), and dimethylformamide (10 mL) is refluxed overnight. The mixture is then transferred to ethyl acetate and extracted with aqueous 10% hydrochloric acid and distilled water. The organic phase is concentrated in vacuo to afford the title compound as a white solid.

Workup

  1. temperatureis refluxed overnight
  2. extractionextracted with aqueous 10% hydrochloric acid
  3. distillationdistilled water
  4. concentrationThe organic phase is concentrated in vacuo

Sources & evidence

ORD record
ord-3d756ccceaa044129120217b41b77447
Source dataset
uspto-grants-2001_05
Patent number
US06235928B1

Reaction notes

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