反应详情

To a mixture of 4-bromocathechol (8.43 g) and potassium carbonate (15.4 g) in DMF (80 ml) was added at room temperature ethyl iodide (7.5 ml), and the mixture was stirred for 15 hours. To the mixture was added water, and the mixture was extracted with hexane. The organic layer was washed with water and saturated brine, dried with magnesium sulfate and concentrated under reduced pressure, and the residue purified with silica gel column chromatography (ethyl acetate/hexane=1:4) to give yellow oil of 4-bromo-1,2-diethoxybenzene (10.06 g).

1. extractionthe mixture was extracted with hexane
2. washThe organic layer was washed with water and saturated brine
3. dry with materialdried with magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customthe residue purified with silica gel column chromatography (ethyl acetate/hexane=1:4)