4-Chlorophenol → 1-(4-Chlorophenoxy)acetone

HRID 1978805Notes

Reaction equation

HRID 1978805 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][C:11](=[O:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][C:11](=[O:13])[CH3:12])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 46844-ChlorophenolHCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium Carbonate

Product 1

HCID 2398741-(4-Chlorophenoxy)acetoneYield 97.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-Chlorophenol (10 g), chloroacetone (10.8 g), anhydrous potassium carbonate (12.9 g) and potassium iodide (1.3 g) were added to acetone (100 ml) and heated under reflux for 6 hours. The reaction mixture was filtered and the filtrate was concentrated to obtain 4-chlorophenoxyacetone (14 g).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 6 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cfa1616d65404d00b9f57ab28c931cd8
Source dataset
uspto-grants-2001_05
Patent number
US06239077B1

Reaction notes

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