反应详情

0.97 ml of methyl cyanoacetate and 0.3 ml of piperidine were added to a solution of 3.3 g of 3-(4-chloro-3-formylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 100 ml of tetrahydrofuran. After the mixture had been stirred for 5 hours at the reflux temperature, a further 0.97 ml of methyl cyanoacetate was added and refluxing was continued for a further 5 hours. The reaction mixture was evaporated down and the oil obtained was chromatographed (dichloromethane). The solid obtained was stirred with diisopropyl ether, isolated, washed with petroleum ether and dried.

1. temperaturerefluxing
2. waitwas continued for a further 5 hours
3. customThe reaction mixture was evaporated down
4. customthe oil obtained
5. customwas chromatographed (dichloromethane)
6. customThe solid obtained
7. customisolated
8. washwashed with petroleum ether
9. customdried