反应详情

A mixture of 1.52 g of N-methyl-4-phenyl-4-piperidyl chloroacetate hydrochloride, 1.77 g of the sodium salt of N-(8-trifluoromethyl-4-quinolyl)-anthranilic acid and 0.7 g of potassium carbonate in 10 ml of dimethylformamide was stirred for 48 hours at 20°-25° C. Upon completion of the reaction, the inorganic salts were filtered off. The solution was evaporated to dryness and treated with water, and the solid collected by filtration. This solid was then refluxed with hexane, filtered and recrystallized from hexane to provide the title compound. M.p. 144°-145° C., yield 1 g (35%).

1. customUpon completion of the reaction
2. filtrationthe inorganic salts were filtered off
3. customThe solution was evaporated to dryness
4. additiontreated with water
5. filtrationthe solid collected by filtration
6. temperatureThis solid was then refluxed with hexane
7. filtrationfiltered
8. customrecrystallized from hexane