Hydrochloric Acid → HCID 178484658, compound

HRID 1979966Notes

Reaction equation

HRID 1979966 reaction equation
C(OC([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]1)=O)(C)(C)C.C(OC([NH:26][CH2:27][C@H:28]1[CH2:33][CH2:32][C@H:31]([C:34]([OH:36])=[O:35])[CH2:30][CH2:29]1)=O)(C)(C)C.[OH:37][CH:38]([OH:44])[C:39]([N:41]([CH3:43])[CH3:42])=[O:40].Cl>C(OCC)(=O)C>[NH2:8][CH2:9][C@H:10]1[CH2:11][CH2:12][C@H:13]([C:16]([OH:18])=[O:17])[CH2:14][CH2:15]1.[NH2:26][CH2:27][C@H:28]1[CH2:29][CH2:30][C@H:31]([C:34]([OH:36])=[O:35])[CH2:32][CH2:33]1.[OH:37][CH:38]([OH:44])[C:39]([N:41]([CH3:43])[CH3:42])=[O:40]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453625HCID 178453625, compound

Product 1

HCID 178484658HCID 178484658, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

2,2-Dihydroxy-N,N-dimethylacetamide bis-[trans-4-(tert.-butyloxycarbonylaminomethyl)cyclohexanecarboxylate] (3 g) was dissolved in ethyl acetate (50 ml) and ethyl acetate containing hydrochloric acid (50 ml) was added. After 2 h the solvent was evaporated and the residue dissolved in methanol and ether was added. The precipitate formed (0.9 g) had a m.p. of 220° C.

Workup

  1. additionwas added
  2. customAfter 2 h the solvent was evaporated
  3. dissolutionthe residue dissolved in methanol
  4. additionether was added
  5. customThe precipitate formed (0.9 g)

Sources & evidence

ORD record
ord-b86a405953444d04bc518a8036b28638
Source dataset
uspto-grants-1984_11
Patent number
US04483867

Reaction notes

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