Hydrochloric Acid → t-Butyl 2-(2-fluoro-4-((pyrazin-2-ylcarbonyl)amino)phenyl)pyrrolidine-1-carboxylate

HRID 198036Notes

Reaction equation

HRID 198036 reaction equation
[CH3:11][N:12]([CH3:13])[CH2:14][CH2:15][CH2:16][N:17]=[C:18]=[N:19][CH2:20][CH3:21].[CH:48]([Cl:49])([Cl:50])[Cl:51].[ClH:10].[NH2:28][c:29]1[cH:30][c:31]([F:47])[c:32]([CH:35]2[N:36]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:37][CH2:38][CH2:39]2)[cH:33][cH:34]1.[cH:22]1[cH:23][cH:24][n:25][cH:26][cH:27]1.[n:1]1[c:2]([C:7](=[O:8])[OH:9])[cH:3][n:4][cH:5][cH:6]1>>[n:1]1[c:2]([C:7](=[O:9])[NH:28][c:29]2[cH:30][c:31]([F:47])[c:32]([CH:35]3[N:36]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:37][CH2:38][CH2:39]3)[cH:33][cH:34]2)[cH:3][n:4][cH:5][cH:6]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 10472-Pyrazinecarboxylic acidHCID 1049PyridineHCID 6212ChloroformHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 23145592t-Butyl 2-(4-amino-2-fluoro-phenyl)-pyrrolidine-1-carboxylate

Product 1

HCID 23145269t-Butyl 2-(2-fluoro-4-((pyrazin-2-ylcarbonyl)amino)phenyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-c26c935a24f34eb5ac5057e7486b57ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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