反应详情

温度

0 °C

A solution of 0.81 g of o-methylbenzoyl chloride (5.25 m mol) in 3 ml of tetrahydrofuran is added dropwise to a solution of 0.81 g of 1,1-dimethyl-4-aminoindan (5.00 m mol) and 0.61 g of triethylamine (6.00 m mol) in 10 ml of tetrahydrofuran, while maintaining the reaction mixture at 0° C. by ice-cooling. Then, reaction mixture is stirred over night at room temperature, and water and ethyl acetate are added to the mixture. The organic layer is washed with 5% hydrochloric acid and water and dried over anhydrous sodium sulfate. After the solvent is removed by distillation, the residue is dried to give 1.31 g of N-(1,1-dimethyl-4-indanyl)-o-methylbenzamide (yield: 93.9%).

1. temperaturecooling
2. customThen, reaction mixture
3. washThe organic layer is washed with 5% hydrochloric acid and water
4. dry with materialdried over anhydrous sodium sulfate
5. customAfter the solvent is removed by distillation
6. customthe residue is dried