Glycolic Acid → Oxolan-2-yl bromoacetate

HRID 1981179Notes

Reaction equation

HRID 1981179 reaction equation
C(O)(=O)CO.[Br:6][CH2:7][C:8]([OH:10])=[O:9].[O:11]1[CH:15]=[CH:14][CH2:13][CH2:12]1>>[O:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[O:9][C:8](=[O:10])[CH2:7][Br:6]

Participants

4

Reactant 3

HCID 757Glycolic Acid2×HCID 6227Bromoacetic Acid2×HCID 709342,3-Dihydrofuran

Product 1

HCID 15391487Oxolan-2-yl bromoacetate

Procedure

The glycolic acid derivative is obtained by reacting 6.95 g (0.05 mol) of bromoacetic acid and 2.80 g (0.4 mol) of 2,3-dihydrofuran at room temperature in the absence of moisture, and stirring the mixture after 5 hours (bromoacetic acid is converted quantitatively). This reaction solution was employed in the following synthesis step, without isolation. The glycolic acid derivative has the formula: ##STR6##

Workup

  1. customat room temperature
  2. customThis reaction solution was employed in the following synthesis step, without isolation

Sources & evidence

ORD record
ord-f946150c48514586b27688c549747d23
Source dataset
uspto-grants-1985_04
Patent number
US04513004

Reaction notes

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