Water → HCID 70457139, compound

HRID 1981856Notes

Reaction equation

HRID 1981856 reaction equation
[OH:1][C:2]1([C:12]#[N:13])[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH2:3]1.[CH:14](Br)([CH3:16])[CH3:15].[H-].[Na+].O>CN(C)C=O>[CH:14]([O:1][C:2]1([C:12]#[N:13])[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH2:3]1)([CH3:16])[CH3:15]

Participants

6

Reactant 4

HCID 962WaterHCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 86740278HCID 86740278, compound

Product 1

HCID 70457139HCID 70457139, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Hydroxy-5,6,7,8-tetrahydro-4-naphthonitrile (1.73 g, 10 mm), isopropyl bromide (0.78 g, 10 mM), and sodium hydride (0.24 g, 10 mM) in dimethyl formamide were stirred for 3 hours. Water was added and the mixture was extracted with ether. The ether was dried and evaporated to give the isopropyl ether (7).

Workup

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether was dried
  3. customevaporated

Sources & evidence

ORD record
ord-fc368feadea643dc87f24cf5ac77fd73
Source dataset
uspto-grants-1986_06
Patent number
US04594195

Reaction notes

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