反应详情

温度

23 °C

A mixture of 79.5 g (1.25 mol) of 3,4-dibenzyloxybenzaldehyde (11) (available from Aldrich Chemical Co.), 47 g CH3CO2NH4, 47 g CH3NO2, and 400 ml CH3CO2H is refluxed for two hours. The mixture is cooled to 23° C. to precipitate the product. The yellow solid is isolated by filtration, washed with ethanol, and air dried. Recrystallization from CH3CO2H--C2H5OH gives 67.2 g (74.5%) of (12): mp 118°-119° C.

1. temperatureis refluxed for two hours
2. customto precipitate the product
3. customThe yellow solid is isolated by filtration
4. washwashed with ethanol, and air
5. customdried
6. customRecrystallization from CH3CO2H