反应详情

2,4,6-trichloroaniline, 49.1 gm, was added to 250 ml of methylene chloride. The solution was cooled to 0° C. to 5° C. After cooling, 34.8 gm of triethylamine was added to the system. Then 21.8 ml of bromoacetyl bromide was added and the system allowed to warm to room temperature. The system was stirred at room temperature for 18 hours. The reaction was then stopped and the methylene chloride solution was washed with saturated sodium bicarbonate solution. The methylene chloride layer was separated and partially stripped when a solid precipitated. The solid was filtered and air dried to yield 41.4 gm of the α-bromo-(2',4',6'-trichlorophenyl)acetamide as a gray solid.

1. temperatureThe solution was cooled to 0° C. to 5° C
2. temperatureAfter cooling
3. washthe methylene chloride solution was washed with saturated sodium bicarbonate solution
4. customThe methylene chloride layer was separated
5. customprecipitated
6. filtrationThe solid was filtered
7. customair dried