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HRID1984091

反应详情

EQUATION

反应方程式

HRID 1984091 的结构方程式

REACTANTS

反应物

4
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=C(Cl)Oc1ccc([N+](=O)[O-])cc1
HCID82129

Carbonochloridic acid, 4-nitrophenyl ester

C7H4ClNO4

结构：CCOC(C)=O.ClCCl
HCID21226138

未命名化合物

结构：C#CCCCN1CCNCC1
HCID86608221

未命名化合物

PRODUCTS

生成物

1
结构：C#CCCCN1CCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)CC1
HCID86608222

4-Nitrophenyl 4-(4-pentyn-1-yl)-1-piperazinecarboxylate

C16H19N3O4

收率 64.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

A solution of 1-(pent-4-ynyl)piperazine (2.2 g) and Et3N (22 mL) in 1,2-dichloroethane (22 mL) was treated with p-nitrophenyl chloroformate (2.9 g) at rt for 10 min. Work-up and silica gel chromatography (DCM:EtOAc 1:3→0:3) gave 4-nitrophenyl 4-(pent-4-ynyl)piperazine-1-carboxylate as a yellow oil (2.96 g).