Lithium Hydroxide → HCID 57717900, compound

HRID 1984860Notes

Reaction equation

HRID 1984860 reaction equation
C[O:2][C:3]([CH:5]1[CH2:14][C:13]2[C:8](=[C:9]([Br:17])[CH:10]=[CH:11][C:12]=2[O:15][CH3:16])[C:7]([CH2:18][CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[N:6]1)=[O:4].[Li+].[OH-]>C1COCC1.CO>[Br:17][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[C:13]2[C:8]=1[C:7]([CH2:18][CH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)=[N:6][C:5]([C:3]([OH:4])=[O:2])=[CH:14]2

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68869428HCID 68869428, compound

Product 1

HCID 57717900HCID 57717900, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a stirring solution of 0.4 g (1.05 mmol) of the above ester in 2.5 ml of THF, 0.6 ml of MeOH was added along with 0.6 ml of 2N LiOH at rt. Usual work up as described in general procedure C gave 0.38 g of title compound as a light yellow solid.

Sources & evidence

ORD record
ord-701c5455011240c3ad42ef083d3801ed
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

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