反应详情

To a solution of 2,4-dichloro-quinazoline obtained in step B of example 1 (4 g, 20 mmol) in THF (50 mL) were added tert-butyl amine (2.15 mL, 20.5 mmol) and diisopropylethylamine (3.5 mL, 21 mmol). The mixture was stirred at ambient temperature for 2 hr. The mixture was concentrated and the residue was dissolved in EtOAc. The organic layer was washed with water, dried over Na2SO4, and filtered. The mixture was concentrated to give tert-butyl-(2-chloro-quinazolin-4-yl)-amine as a white solid (3 g, 64%).

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in EtOAc
3. washThe organic layer was washed with water
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationThe mixture was concentrated