反应详情

Benzyl bromide (0.02 mL, 0.179 mmol, d=1.438) and tetrabutyl ammonium iodide (catalytic amount) are added to a 0° C. suspension of 2-(2-Fluoro-phenoxy)-2-methyl-3-{4-[2-(3-methyl-2-oxo-imidazolidin-4-yl)-ethoxy]-phenyl}-propionic acid ethyl ester (0.053 g, 0.119 mmol) and sodium hydride (0.012 g, 0.298 mmol, 60% suspension on mineral oil), pre-stirred for 1 h at ambient temperature. The reaction mixture is stirred at ambient temperature for 18 h, diluted with ethyl acetate, and washed with 1N HCl, water, and brine. The organic layer is dried over MgSO4 and concentrated in vacuo to provide the title compound, which is carried into the next step. MS [EI+] 535 (M+H)+.

1. stirringThe reaction mixture is stirred at ambient temperature for 18 h
2. washwashed with 1N HCl, water, and brine
3. dry with materialThe organic layer is dried over MgSO4
4. concentrationconcentrated in vacuo