Hydrochloric Acid → (+)-6-[Amino-(6-Chloro-Pyridin-3-yl)-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Chloro-Phenyl)-1-Cyclopropylmethyl-1H-Quinolin-2-One

HRID 198531Notes

Reaction equation

HRID 198531 reaction equation
[C:48](=[O:49])([O-:50])[O-:51].[CH2:60]1[O:61][CH2:62][CH2:63][CH2:64]1.[CH3:54][CH2:55][O:56][C:57](=[O:58])[CH3:59].[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:46])[n:11]([CH2:42][CH:43]3[CH2:44][CH2:45]3)[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[n:20]([CH3:24])[cH:21][n:22][cH:23]4)([N:25]=[CH:26][c:27]4[cH:28][cH:29][c:30]([O:31][CH3:32])[cH:33][cH:34]4)[c:35]4[cH:36][n:37][c:38]([Cl:41])[cH:39][cH:40]4)[cH:16][c:17]23)[cH:5][cH:6][cH:7]1.[ClH:47].[K+:52].[K+:53]>>[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:46])[n:11]([CH2:42][CH:43]3[CH2:44][CH2:45]3)[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[n:20]([CH3:24])[cH:21][n:22][cH:23]4)([NH2:25])[c:35]4[cH:36][n:37][c:38]([Cl:41])[cH:39][cH:40]4)[cH:16][c:17]23)[cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 120507314-(3-chloro-phenyl)-6-[(6-chloro-pyridin-3-yl)-[(4-methoxy-benzylidene)-amino]-(3-methyl-3H-imidazol-4-yl)-methyl]-1-cyclopropylmethyl-1H-quinolin-2-one

Product 1

HCID 9849901(+)-6-[Amino-(6-Chloro-Pyridin-3-yl)-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Chloro-Phenyl)-1-Cyclopropylmethyl-1H-Quinolin-2-One

Sources & evidence

ORD record
ord-5c0c1164fdf6415b880c12e4b1f5d466
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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