Diethyl Carbonate → Ethyl 3-(2,4-dichlorophenyl)-3-oxopropanoate

HRID 1985621Notes

Reaction equation

[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[Cl:11])=[O:3].[CH2:12]([O:14][C:15](=O)[O:16]CC)[CH3:13].[H-].[Na+]>>[CH2:12]([O:14][C:15](=[O:16])[CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[Cl:11])=[O:3])[CH3:13]

Participants

Reactant 3

HCID 7766Diethyl Carbonate

HCID 166932',4'-Dichloroacetophenone

HCID 24758Sodium hydride

Product 1

HCID 542007Ethyl 3-(2,4-dichlorophenyl)-3-oxopropanoate

Procedure

Synthesis of Intermediate 1a was done by standard procedure starting from 2,4-dichloroacetophenone, diethylcarbonate (25 eq) and NaH (2 eq) at 80° C. for 60 minutes.

Sources & evidence

ORD record: ord-ce0bdbce82ca47e0984ad2ce2455a08f
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07547679B2

Reaction notes

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