Hydrochloric Acid → HCID 68856131, compound

HRID 1986218Notes

Reaction equation

HRID 1986218 reaction equation
[Li+].[OH-].C[O:4][C:5]([C:7]1[C:15]2[CH:14]=[C:13]([C:16]3[C:21]([Cl:22])=[CH:20][N:19]=[C:18]([NH:23][CH2:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]4)[N:17]=3)[S:12][C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:6].[ClH:34]>O.CO.C1COCC1>[ClH:22].[ClH:34].[ClH:22].[Cl:22][C:21]1[C:16]([C:13]2[S:12][C:11]3[CH:10]=[CH:9][CH:8]=[C:7]([C:5]([OH:6])=[O:4])[C:15]=3[CH:14]=2)=[N:17][C:18]([NH:23][CH2:24][CH2:25][CH2:26][N:27]2[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]2)=[N:19][CH:20]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68858417HCID 68858417, compound

Product 1

HCID 68856131HCID 68856131, compoundYield 94%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

Aqueous 2 N LiOH (1.1 mL, 2.2 mmol) is added to a stirred solution of 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid methyl ester (280 mg, 0.610 mmol) in water (3 mL), MeOH (6 mL) and THF (12 mL). The mixture is heat at 70° C. for 2 hours. While at 70° C., 5 N HCl (1 mL) is added to the solution, then the solution is allowed to cool to room temperature. After concentration, the yellow solid is suspended in THF (20 mL), sonicated, filtered, and dried to give the title compound as a solid (320 mg, 94% yield).

Workup

  1. temperatureto cool to room temperature
  2. concentrationAfter concentration
  3. customsonicated
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-bb17636c45834759a3c86b44c2f0a730
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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