反应详情

121 mg of sodium hydride as a 60% suspension in oil (3.05 mmol) are introduced at room temperature into a 50 ml round-bottomed flask, with stirring and under an argon atmosphere, containing 20 ml of DMF and 500 mg of 26 (2.03 mmol). The medium is stirred for 1 hour and 489 mg (2.03 mmol) of 4-bromomethyl-2,6-dichloropyridine are then added. The medium is stirred for 3 hours, 50 ml of EtOAc and 50 ml of water are added to the reaction medium and, after separation of the phases by settling, the organic phase is washed once with 50 ml of water. The organic phase is dried, filtered and then evaporated to dryness. 1.5 g of crude product are recovered, which product is chromatographed on a silica cartridge (20 g) with an 80/20 heptane/EtOAc mixture. 190 mg of product 36 are recovered (yield=23%).

1. stirringThe medium is stirred for 1 hour
2. stirringThe medium is stirred for 3 hours
3. customafter separation of the phases
4. washthe organic phase is washed once with 50 ml of water
5. customThe organic phase is dried
6. filtrationfiltered
7. customevaporated to dryness
8. custom1.5 g of crude product are recovered
9. customwhich product is chromatographed on a silica cartridge (20 g) with an 80/20 heptane/EtOAc mixture
10. custom190 mg of product 36 are recovered (yield=23%)