Tetrahydrofuran → Tert-butyl[4-(4-butoxybenzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamate

HRID 1986543Notes

Reaction equation

HRID 1986543 reaction equation
[H-].[Na+].C1COCC1.[O:8]=[C:9]1[CH:15]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:14][S:13][CH2:12][CH2:11][NH:10]1.[CH2:24]([O:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1)[CH2:25][CH2:26][CH3:27]>O.CCOC(C)=O>[CH2:24]([O:28][C:29]1[CH:30]=[CH:31][C:32]([CH2:33][N:10]2[C:9](=[O:8])[CH:15]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:14][S:13][CH2:12][CH2:11]2)=[CH:35][CH:36]=1)[CH2:25][CH2:26][CH3:27]

Participants

7

Reactant 4

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 127852661-(Bromomethyl)-4-butoxybenzeneHCID 15591256(Hexahydro-5-oxo-1,4-thiazepin-6-yl)carbamic acid, (1,1-dimethylethyl) ester

Product 1

HCID 57722320Tert-butyl[4-(4-butoxybenzyl)-5-oxoperhydro-1,4-thiazepin-6-yl]carbamateYield 156.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

81 mg of sodium hydride as a 60% suspension in oil (2.03 mmol) are introduced at room temperature into a 25 ml round-bottomed flask, with stirring and under an argon atmosphere, containing 20 ml of THF and 500 mg of 26 (2.03 mmol). The medium is stirred for 1 hour and 1.1 g (2.34 mmol) of 4-butoxybenzyl bromide are then added. The medium is stirred for 16 hours, 20 ml of EtOAc and 20 ml of water are added to the reaction medium and, after separation of the phases by settling, the organic phase is washed with 10 ml of water. The organic phase is dried, filtered and then evaporated to dryness to give 1.3 g of crude product, which product is chromatographed on a silica cartridge (25 g) with a 90/10 heptane/EtOAc mixture. 420 mg of product 39 are recovered (yield=53%).

Workup

  1. stirringThe medium is stirred for 1 hour
  2. stirringThe medium is stirred for 16 hours
  3. customafter separation of the phases
  4. washthe organic phase is washed with 10 ml of water
  5. customThe organic phase is dried
  6. filtrationfiltered
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-5aa79f004d4d4cc7a136726e0e2de470
Source dataset
uspto-grants-2009_06
Patent number
US07550453B2

Reaction notes

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