反应详情

After suspending 4-amino-3-chlorophenol (23.7 g) in N,N-dimethylformamide (100 mL) and adding pyridine (23.4 mL) while cooling in on ice, phenyl chloroformate (23.2 mL) was added dropwise below 20° C. Stirring was performed at room temperature for 30 min, and then water (400 mL), ethyl acetate (300 mL) and 6N-HCl (48 mL) were added, the mixture was stirred, and the organic layer was separated. The organic layer was washed twice with a 10% aqueous solution of sodium chloride (200 mL), and dried over magnesium sulfate. The solvent was removed to give 46 g of the titled compound as a solid.

1. additionwas added dropwise below 20° C
2. stirringthe mixture was stirred
3. customthe organic layer was separated
4. washThe organic layer was washed twice with a 10% aqueous solution of sodium chloride (200 mL)
5. dry with materialdried over magnesium sulfate
6. customThe solvent was removed