反应详情

温度

90 °C

52.5 g (0.28 mol) of p-toluenesulfonyl chloride were initially introduced into 50 ml of dimethylformamide and 22.6 g (0.29 mol) of sodium acetate were introduced with stirring and ice-cooling. The mixture was subsequently stirred for one hour, treated with 39.1 g of formaldehyde diethyl acetal and again subsequently stirred for one hour. 41.5 g of 3-methylxanthine were then introduced and the reaction mixture was heated at 90° C. for 2 hours. After cooling to 10° C., the precipitated product was filtered off with suction, washed with a little dimethylformamide and washed with demineralized water until chloride-free. The crude product obtained was recrystallized from dimethylformamide.

1. additionwere introduced
2. temperatureice-cooling
3. stirringThe mixture was subsequently stirred for one hour
4. stirringagain subsequently stirred for one hour
5. temperatureAfter cooling to 10° C.
6. filtrationthe precipitated product was filtered off with suction
7. washwashed with a little dimethylformamide
8. washwashed with demineralized water until chloride-free