Hydrochloric Acid → HCID 69078521, compound

HRID 1987160Notes

Reaction equation

HRID 1987160 reaction equation
C([CH2:8][C:9]([CH3:20])([OH:19])[CH:10]([NH2:18])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(OC(C)(C)C)=O.[ClH:21]>C(OCC)(=O)C>[ClH:21].[NH2:18][CH:10]([CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:9]([CH3:8])([OH:19])[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69077265HCID 69077265, compound

Product 1

HCID 69078521HCID 69078521, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of Boc-3-amino-2-methyl-4-phenylbutan-2-ol (0.34 g, 1.2 mmol) in 100 mL ethyl acetate was saturated with HCl gas and stirred at ambient temperature for 1 hour. The reaction was evaporated in vacuo to give 3-amino-2-methyl-4-phenylbutan-2-ol hydrochloride as a white solid: 1H NMR (400 MHz, CDCl3) δ 8.05 (bs, 2H), 7.33 (m, 5H), 3.34 (m, 1H), 3.02 (m, 2H), 1.37 (s, 3H), 1.33 (s, 3H).

Workup

  1. customThe reaction was evaporated in vacuo

Sources & evidence

ORD record
ord-375f3e2c414b43fc9fd5fef00d433de2
Source dataset
uspto-grants-2009_06
Patent number
US07550481B2

Reaction notes

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