Methanesulfonic Acid → HCID 86615031, compound

HRID 1988841Notes

Reaction equation

HRID 1988841 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[F:6][C:7]1[CH:29]=[CH:28][C:10]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][N:16]=[C:15]3[C:19]([CH3:27])=[C:20]([CH3:26])[N:21]([CH2:22][CH2:23][O:24][CH3:25])[C:14]=23)=[CH:9][CH:8]=1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[F:6][C:7]1[CH:29]=[CH:28][C:10]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][N:16]=[C:15]3[C:19]([CH3:27])=[C:20]([CH3:26])[N:21]([CH2:22][CH2:23][O:24][CH3:25])[C:14]=23)=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11653485HCID 11653485, compound

Product 1

HCID 86615031HCID 86615031, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.039 ml of Methanesulfonic acid was added at room temperature to a solution of 7-(4-fluorobenzyloxy)-1-(2-methoxyethyl)-2,3-dimethyl-1H-pyrrolo[3,2-b]pyridine (200 mg, 0.609 mmol) prepared in Example 122 in 10 ml of ethyl acetate and then stirred for 24 hours at the same temperature. The resulting solid was filtered to give the titled compound as a white solid. (Yield: 85.1%)

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-d034238beb534662ac33570368d238ab
Source dataset
uspto-grants-2010_01
Patent number
US07642269B2

Reaction notes

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