Methylamine → HCID 59128613, compound

HRID 1990698Notes

Reaction equation

HRID 1990698 reaction equation
[CH3:1][NH2:2].[C:3]1([C:9]2[N:14]=[CH:13][C:12]([CH2:15][CH2:16][NH:17][C:18]([O:20][CH2:21][C:22]([O:24]CC)=O)=[O:19])=[CH:11][CH:10]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCCC1.CO>[C:3]1([C:9]2[N:14]=[CH:13][C:12]([CH2:15][CH2:16][NH:17][C:18](=[O:19])[O:20][CH2:21][C:22]([NH:2][CH3:1])=[O:24])=[CH:11][CH:10]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 86610100HCID 86610100, compound

Product 1

HCID 59128613HCID 59128613, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

4.6 ml (9.17 mmol) of a solution of methylamine (2M) in tetrahydrofuran are added to a solution of 1.0 g (3.06 mmol) of ethyl ({[2-(6-phenylpyrid-3-yl)ethyl]amino}carbonyl)-oxyacetate, obtained in stage 1.3., in 6 ml of methanol. Stirring is continued at ambient temperature for 4 hours.

Workup

  1. customobtained in stage 1.3

Sources & evidence

ORD record
ord-36acfbdf53254cf4959291d22bcfcc0f
Source dataset
uspto-grants-2010_01
Patent number
US07645757B2

Reaction notes

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