Indole → HCID 13340133, compound

HRID 1990699Notes

Reaction equation

HRID 1990699 reaction equation
[OH-].[Na+].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4]1.[Br:12][CH2:13][CH2:14][CH2:15][CH2:16]Br>CN(C)C=O>[Br:12][CH2:13][CH2:14][CH2:15][CH2:16][N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4]1

Participants

5

Reactant 3

HCID 798IndoleHCID 80561,4-DibromobutaneHCID 14798Sodium Hydroxide

Product 1

HCID 13340133HCID 13340133, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.96 g (17.07 mmol) of sodium hydroxide is added in small portions to a solution, cooled by a bath of ice-cold water, of 2 g (17.07 mmol) of 1H-indole and of 1.15 ml (51.22 mmol) of 1,4-dibromobutane in 80 ml of dimethylformamide. The bath is removed and stirring is continued at ambient temperature for 15 hours.

Workup

  1. customThe bath is removed

Sources & evidence

ORD record
ord-4685b173ec6b4b489e5eefb0aef44c32
Source dataset
uspto-grants-2010_01
Patent number
US07645757B2

Reaction notes

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